Spring 2015 was active from earthquakes to tornado outbreaks to an early tropical system.

In April, the Nepal earthquake killed more than 8,800 people and injured more than 23,000. It occurred on 25 April with a magnitude of 7.8. Its epicenter was east of the district of Lamjung, and its hypocenter was at a depth of approximately 9.3 miles. It was the worst natural disaster to strike Nepal since the 1934 Nepal–Bihar earthquake. The earthquake triggered an avalanche on Mount Everest, killing at least 19, making April 25, 2015 the deadliest day on the mountain in history. Hundreds of thousands of people were made homeless with entire villages flattened, across many districts of the country. Centuries-old buildings were destroyed in the Kathmandu Valley.

In May, severe weather targeted the Plains causing major damage. The tornado outbreak began on May 5 with isolated tornadoes in western Texas. More widespread and significant activity occurred on May 6. Much of central Oklahoma experienced tornadoes, and the town of Bridge Creek sustained major impacts from a large EF2 wedge tornado, where several businesses and homes were heavily damaged or destroyed. Another EF2 tornado caused major damage in southwestern parts of Oklahoma City, just north of Valley Brook, where a hotel, several self-storage units, a mobile home park, and an RV park were heavily damaged, numerous vehicles were flipped, and at least 12 people were injured. Large, strong tornadoes, including two EF3s, severely damaged or completely destroyed rural homes near the Kansas towns of Mount Hope, Scandia, and Munden. Several additional less intense tornadoes occurred on May 7 and May 8 across an area extending from Colorado to Texas. Another wave of significant tornado activity occurred on May 9 throughout an area extending from Nebraska to Texas. This included a large EF3 cone tornado that caused major damage near Cisco, Texas. Destructive tornado activity continued on May 10, as a large tornado struck the town of Delmont, South Dakota, where severe structural damage and multiple injuries occurred.

On May 8, Subtropical Storm Ana formed in the Atlantic Ocean. Amid the warm waters of the Gulf Stream and abnormally cold upper-level temperatures, Ana intensified to reach peak winds of 60 mph by late on May 8, and on the following day, the system completed its transition to a fully tropical cyclone. Diminished by cooler waters and persistent dry air, the system moved ashore north of Myrtle Beach, South Carolina, on May 10, with winds of 45 mph. Along the North Carolina–South Carolina border, Ana produced moderate rainfall with accumulations peaking at 6.7 in southeast of Kinston, North Carolina. Minor street flooding took place in the city while beaches in both states experienced 2–4 ft of erosion. Upon moving ashore, it became the second-earliest cyclone to strike the United States on record, preceded only by the 1952 Groundhog Day tropical storm.

The Climate Prediction Center is forecasting below normal precipitation across parts of the Pacific Northwest and above normal precipitation across the Plains and Deep South.

The Climate Prediction Center is forecasting above normal temperatures across the West and Southeast with below normal temperatures across the Plains.